Ana Paula Serro

Fotografia: Ana Paula Serro

Assistant Professor

Chemical Engineering Department, Instituto Superior Técnico, University of Lisbon

Degree in Chemical Engineering, Instituto Superior Técnico, 1994

PhD in Chemistry (Biomaterials), Instituto Superior Técnico, 2001

Telephone: +352 21 8419240


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Scientific affiliations

I am researcher of CQE - Centro de Química Estrutural and CiiEM - Centro de investigação Interdisciplinar Egas Moniz and Coordinator of the Biomaterials Research Group at IST. Currently my research group has two main research lines: (RL1) Hydrogel based materials for therapeutic applications (RL2) Dental materials

Present research interests

  • Controlled drug release;
  • Biomaterials characterization;
  • Biotribology;
  • Adsorption of biomolecules onto biomaterials;
  • Sterilization

Research projects

  • "SurfLenses - Surface modifications to control drug release from therapeutic ophthalmic lenses" M-ERA.NET/0005/2012 (2013-2017) (Coordinator)
  • "STEReoSTRAT - "Sterilization of clinically active hydrogels: looking for efficient strategies", PTDC/CTM-BIO/3640/2014 (2016-2019) (Coordinator)
  • "3D-DentalPrint - Additive manufacturing of zirconia and nanostructured alumina/zirconia dental prosthesis", 02/SAICT/2016/023940 (2017-2019) (Coordinator)
  • "CartHeal - Cartilages for hip prosthesis with controlled drug release ability", PTDC/CTM-CTM/29593/2017 (2018-2021) (Coordinator)
  • ORBITAL - Ocular Research By Integrated Training And Learning, H2020-MSCA-ITN-2018 Proposal Number: SEP-210492283 (2019-2023) (Partner Coordinator)

Main publications in the last 5 years


  • P. Paradiso, R. Galante, L. Santos, A.P. Alves de Matos, R. Colaço, A.P. Serro, B. Saramago; Comparison of two hydrogel formulations for drug release in ophthalmic lenses. Journal of Biomedical Materials Research Part B: Applied Biomaterials 102(6) (2014) 1170-1180. 10.1002/jbm.b.33099
  • P. Paradiso, L. Santos, V. Chu, A.P. Serro, R. Colaço, B. Saramago; Effect of plasma treatment on the performance of two drug-loaded hydrogel formulations for therapeutic contact lenses. Journal of Biomedical Materials Research Part B: Applied Biomaterials 103(5) (2015)1059-1068.
  • R. Galante, P. Paradiso, M.G. Moutinho, A.I. Fernandes, J.L. Mata, R. Colaço, B. Saramago, A.P. Serro; About the effect of eye blinking on drug release from pHEMA based hydrogels: an in vitro study. Journal of Biomaterials Science: Polymer Edition, 26(4) (2015) 235-251.
  • D. Silva, A. Fernandes, T. Nunes, R. Colaço, A.P. Serro; The effect of albumin and cholesterol on the biotribological behaviour of hydrogels for contact lenses. Acta Biomaterialia 26 (2015) 184-194. 10.1016/j.actbio.2015.08.011
  • P. Paradiso, A.P. Serro, B. Saramago, R. Colaço, A. Chauhan; Controlled release of antibiotics from vitamin-E loaded silicone-hydrogel contact lenses, Journal of Pharmaceutical Sciences. 105(3) (2016) 1164-1172.
  • H.P. Filipe, J. Henriques, P. Reis, P.C. Silva, M.J. Quadrado, A.P. Serro; Contact lenses as drug controlled release systems. A narrative review. Revista Brasileira de Oftalmologia 75(3) (2016) 241-247.
  • A.F.R. Pimenta, A. Valente, J.M.C Pereira, J.C.F Pereira, H.P. Filipe, J.L.G. Mata, R. Colaço, B. Saramago, A.P. Serro; Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling. Drug Delivery and Translational Research 6(6) (2016) 755-762.
  • D. Silva, L.F.V. Pinto, D. Bozukova, L.F. Santos, A.P. Serro, B. Saramago; Chitosan/alginate based multilayers to control drug release from ophthalmic lens. Colloids and Surfaces B: Biointerfaces 147 (2016) 81-89.
  • R. Galante, C.F. Rediguieri, I.S. Kikuchi, P.A.S. Vasquez, R. Colaço, A.P. Serro, T.J.A. Pinto; About the sterilization of chitosan hydrogel nanoparticles. PLoS ONE 11(12) (2016) e0168862: 1-18.
  • A.F.R. Pimenta, J. Ascenso, J.C.S. Fernandes, R. Colaço, A.P. Serro, B. Saramago; Controlled drug release from hydrogels for contact lenses: drug partitioning and diffusion. International Journal of Pharmaceutics 515(1-2) (2016) 467-475.
  • A.F.R. Pimenta, A.P. Serro, P. Paradiso, B. Saramago, R. Colaco; Diffusion-based design of multi-layered ophthalmic lenses for controlled drug release. PLoS ONE 11(12) (2016) e0167728: 1-15.
  • P. Paradiso, R. Colaço, J.L.G. Mata, R. Krastev, B. Saramago, A.P. Serro; Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect. Journal of Biomedical Materials Research Part B: Applied Biomaterials 105B (2017) 1799-1807.
  • R. Galante, D Ghisleni, P. Paradiso, V.D. Alves, T.J.A. Pinto, R. Colaço, A.P. Serro; Sterilization of silicone-based hydrogels for biomedical application using ozone gas: comparison with conventional techniques. Materials Science and Engeneering C 78 (1) (2017) 389-397.
  • A.F.R. Pimenta, A.P. Vieira, R. Colaço, B. Saramago, M.H. Gil, P. Coimbra, P. Alves, D. Bozukova, T.R. Correia, I.J. Correia, A.J. Guiomar, A.P. Serro; Controlled release of moxifloxacin from intraocular lenses modified by Ar plasma-assisted grafting with AMPS or SBMA: an in vitro study. Colloids and Surfaces B: Biointerfaces 156(1) ( 2017) 95-103.
  • A.P Vieira, A.F.R. Pimenta, D. Silva, M.H. Gil, P. Alves, P. Coimbra, J.L.G.C. Mata, D. Bozukova, T.R. Correia, I.J. Correia, A.P. Serro, A.J. Guiomar; Surface modification of an intraocular lens material by plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA), for controlled release of moxifloxacin. European Journal of Pharmaceutics and Biopharmaceutics 120 (2017) 52-62.
  • R. Galante, T.J.A. Pinto, R. Colaço, A.P. Serro; Sterilization of Hydrogels for Biomedical Applications: A Review. Journal of Biomedical Materials Research Part B: Applied Biomaterials 106B (2018) 2472-2492
  • R. Galante, A.S. Oliveira, A. Topete, D. Ghislenia, M. Braga, T.J.A. Pinto, R. Colaço, A.P. Serro; Drug-eluting silicone hydrogel for therapeutic contact lenses: impact of sterilization methods on the system performance. Colloids and Surfaces B: Biointerfaces 161 (2018) 537-546.
  • A. Topete, A.S. Oliveira, A. Fernandes, T.G. Nunes, A.P. Serro, B. Saramago; Improving sustained drug delivery from ophthalmic lens materials through the control of temperature and time of loading. European Journal of Pharmaceutic Sciences 14:117 (2018) 107-117.
  • A.F.R. Pimenta, A.P. Serro, R. Colaço, A. Chauhan; Drug delivery to the eye anterior chamber by intraocular lenses: an in vivo concentration estimation model. European Journal of Pharmaceutics and Biopharmaceutics 133 (2018) 63-69.
  • D. Silva, H.C. Sousa, M.H. Gil, L.F. Santos, M.G. Moutinho, A.P. Serro, B. Saramago; Antibacterial layer-by-layer coatings to control drug release from soft contact lenses material. International Journal of Pharmaceutics 553(1-2) (2018)186-200.
  • A. Topete, A.P. Serro, B. Saramago; Dual drug delivery from intraocular lens material for prophylaxis of endophthalmitis in cataract surgery. International Journal of Pharmaceutics 558(10) (2019) 43-52
  • A.F.R. Pimenta, A.P. Serro, R. Colaço, A. Chauhan; Optimization of intraocular lens hydrogels for dual drug release: experimentation and modelling. European Journal of Pharmaceutics and Biopharmaceutics 141 (2019) 51-57
  • H.P. Filipe, D. Bozukova, A. Pimenta, A.P. Vieira, A.S. Oliveira, R. Galante, A. Topete, M. Masson, P. Alves, P. Coimbra, M.H. Gil, A.J. Guiomar, J. Mata, R. Colaço, B. Saramago, L. Werner, N. Mamalis, A.P. Serro, Moxifloxacin-loaded acrylic intraocular lenses: in vitro and in vivo performance. Journal of Cataract and Refractive Surgery 45 (2019) 1808-1817.
  • A.S. Oliveira, O. Seidi, N. Ribeiro, R. Colaço, A.P. Serro, Tribomechanical comparison between PVA hydrogels obtained using different processing conditions and human cartilage. Materials 12(20) (2019) 3413 (1-17).


  • C.G. Figueiredo-Pina, N. Patas, J. Canhoto, R. Cláudio, S. Olhero, A.P. Serro, A. C. Ferro, M. Guedes; Tribological behaviour of unveneered and veneered lithium disilicate dental material. Journal of the Mechanical Behavior of Biomedical Materials 43 (2016) 226-238.
  • F.T. Rodrigues, A.P. Serro, M. Polido, A. Ramalho, C.G. Figueiredo-Pina; Effect of bleaching teeth with hydrogen peroxide on the morphology, hydrophilicity, mechanical and tribological properties of enamel. Wear 374-375 (2016) 21-28.
  • F. Santos, A. Branco, M.C. Polido, A.P. Serro, C.G. Figueiredo-Pina; Comparative study of the wear of the pair human teeth/Vita Enamic vs commonly used dental ceramics through chewing simulation. Journal of the Mechanical Behavior of Biomedical Materials, 20:88 (2018) 251-260.
  • A.C. Branco, V. Moreira, J.A. Reis, R. Colaço, C.G. Figueiredo-Pina, A.P. Serro; Influence of contact configuration and lubricating conditions on the microtriboactivity of the zirconiar-Ti6Al4V pair used in dental aplications. Journal of the Mechanical Behavior of Biomedical Materials 91 (2019) 164-173.
  • R. Galante, C.G. Figueiredo-Pina, A.P. Serro; Additive manufacturing of ceramics for dental applications: a review. Dental Materials 35 (2019) 825-846.
  • A. C. Branco, J. Brito, M. Codorniz, M. Steinhausen, F. Martins, J. Reis, P. Maurício, R. Colaço, A.P. Serro, Tribological behavior of restorative dental microcomposites after exposure to mouth acids. Tribology Letters 67:90 (2019) 1-10.
  • A.C. Branco, N. Ribeiro, C.G. Figueiredo-Pina, R. Colaço, A.P. Serro; Characterization of the nanostructure of collagen fibers following the application of dilute hydrogen peroxide used in dental whitening treatments. Analytical Letters (in publication).
  • A.C. Branco, R. Silva, T. Santos, H. Jorge, A.R. Rodrigues, R. Fernandes, S. Bandarra, I. Barahona, A.P.A. Matos, K. Lorenz, M. Polido, R. Colaço, A.P. Serro, C.G. Figueiredo-Pina; Suitability of 3D printed nanostructured zirconia pieces for dental applications. Dental Materials (2020) (in publication)